This XNAT database contains anonymized imaging datasets public available from the Neuropsychiatric Imaging Research Laboratory at Duke University. To access the database, register for an account by completing the registration form and agreeing to the Data Usage Agreement.

Datasets currently available are:

MIRIAD

The MIRIAD project is a multiple institution effort for high quality automated analyses of proton density (PD) and T2-weighted MRIs from a longitudinal study of depression in late life. Dual-echo MRI scans acquired at Duke were anonymized and uploaded by the Neuropsychiatric Imaging Research Laboratory (NIRL) to the BIRN SRB where they were accessed at BWH (Surgical Planning Laboratory, SPL) and UCLA (Laboratory of Neuro Imaging, LONI). At LONI, a study-specific atlas was constructed from the MRI scans with both PD and T2 contrasts. Scans were linearly aligned to the study space to acquire spatial normalization factors, and a BWH tissue and structure probability field atlas was non-linearly aligned to each individual subject. Dual-echo scans were segmented utilizing the individual subject-aligned tissue probability atlases at the Surgical Planning Laboratory, SPL; regions of interest and cerebral tissues were classified by an expectation maximization algorithm. LONI completed the scan processing with a measurement of lobar volumes via a non-linear registration of study-specific lobar atlas to native subject spaces, and regional and lobar tissue volumes are computed.

ELUDE

The ELUDE dataset is an anonymized collection of a longitudinal study of late-life depression at Duke University. There are 281 depressed subjects and 154 controls included. An MR scan of each subject was obtained every 2 years for up to 8 years (total of 1093 scans). Clinical assessments occurred more frequently and consists of a battery of psychiatric tests including several depression-specific tests such as the HAM-D, CESD, and MADRS.